cAMP-independent signal pathways stimulate hyphal morphogenesis inCandida albicans
نویسندگان
چکیده
منابع مشابه
Enterococcus faecalis inhibits hyphal morphogenesis and virulence of Candida albicans.
The Gram-positive bacterium Enterococcus faecalis and the fungus Candida albicans are both found as commensals in many of the same niches of the human body, such as the oral cavity and gastrointestinal (GI) tract. However, both are opportunistic pathogens and have frequently been found to be coconstituents of polymicrobial infections. Despite these features in common, there has been little inve...
متن کاملCandida albicans hyphal morphogenesis occurs in Sec3p-independent and Sec3p-dependent phases separated by septin ring formation.
The growing tips of Candida albicans hyphae are sites of polarized exocytosis. Mammalian septins have been implicated in regulating exocytosis and C. albicans septins are known to localize at hyphal tips, although their function here is unknown. Here, we report that C. albicans cells deleted of the exocyst subunit gene SEC3 can grow normal germ tubes, but are unable to maintain tip growth after...
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The formation of hyphae that grow solely by apical extension is a defining feature of filamentous fungi. Hyphal morphogenesis involves several key steps, including the establishment and maintenance of a stable polarity axis, as well as cell division via the deposition of septa. Several filamentous fungi have been employed in attempts to decipher the mechanisms underlying these steps. Amongst th...
متن کاملThe Fungal Pathogen Candida albicans Autoinduces Hyphal Morphogenesis by Raising Extracellular pH
UNLABELLED pH homeostasis is critical for all organisms; in the fungal pathogen Candida albicans, pH adaptation is critical for virulence in distinct host niches. We demonstrate that beyond adaptation, C. albicans actively neutralizes the environment from either acidic or alkaline pHs. Under acidic conditions, this species can raise the pH from 4 to >7 in less than 12 h, resulting in autoinduct...
متن کاملThe Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage
1 Aberdeen Fungal Group, MRC Centre for Medical Mycology, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Institute of Medical Sciences, Aberdeen, United Kingdom, 2 Mucosal & Salivary Biology Division, Dental Institute, King’s College London, United Kingdom, 3 Department of Microbial Pathogenicity Mechanisms, Hans Knoell Institute, and Friedrich Schiller University, ...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2016
ISSN: 0950-382X
DOI: 10.1111/mmi.13588